Exemestane (Aromasin) (Chemical Formula is C₂₀H₂₄O₂) is another powerful medication used to treat specific breast cancer among women. It is included in the class of anti-estrogens called aromatase inhibitors, which tend to inhibit aromatase, causing cancer cells to develop reversibly. It has been shown in studies that the cause of acquiring breast cancer occurs when levels of estrogen in your body arise. Cancers have estrogen receptors called ER positive. Aromatase, for that matter, is a catalyst enzyme that produces estrogen. Taking Exemestane inhibits the growth and development of estrogen synthesis, thereby slowing the spread of cancer—may even prevent it by blocking the process.
Exemestane has also been used for off-label purposes in bodybuilding, and sports as an aromatase inhibitor, meaning it blocks the production of the enzyme aromatase, which is responsible for converting androgens into estrogens. This makes it effective in treating both premenopausal and postmenopausal women with breast cancer and men with prostate cancer. Bodybuilders tend to argue that it is one of the most effective anti-estrogen. It is good to prevent gynecomastia and helps to prevent water retention and weight loss and not to lose muscle mass.
As discussed above, it is a steroidal aromatase inhibitor used to treat ER-positive breast cancer in women. It can also be administered with other cancer treatments, such as surgery and chemotherapy, in postmenopausal women. Just like any other synthetic androgen, Exemestane gives off the same results. It selectively binds and reverses inhibition of aromatase enzyme that causes the blocking of transforming cholesterol to pregnenolone (a steroid hormone), including the outlying aromatization of androgens, which increases levels of estrogen. As an overview, estrogen’s primary source is the ovaries in premenopausal women; on the other hand, in postmenopausal women is produced by transforming androgens into estrogens through aromatase enzyme synthesis in the peripheral tissues, in that case, the breast. Estrogen production can be locally active in these outlying tissues when the aromatase enzyme is present. The apparent presence of estrogen in postmenopausal women and in males can result in the escape of estrogen in the local metabolism after entering the circulatory system. When this happens, cancer cells usually activate. Exemestane has a molecular weight of 296.4 g/mol.
Exemestane was first developed by pharmaceutical companies Pharmacia & Upjohn in the 1990s. It was approved by the US Food and Drug Administration (FDA) in 1999 as a treatment for advanced breast cancer in postmenopausal women. It has since become a widely used drug for treating breast cancer and other hormone-sensitive cancers.
Exemestane is sometimes used off-label by bodybuilders to reduce estrogen levels. When testosterone is taken in large doses, it can be converted into estrogen by the enzyme aromatase. This can lead to side effects such as water retention, gynecomastia, and fat gain. By taking Exemestane, bodybuilders can reduce the conversion of testosterone into estrogen and thus reduce or eliminate these side effects.
Exemestane is also sometimes used by athletes to improve athletic performance. As mentioned above, Exemestane reduces estrogen levels in the body. Lower estrogen levels can result in increased strength, muscle gain, and improved recovery and endurance. However, Exemestane is banned by many sporting organizations, including the World Anti-Doping Agency (WADA), so athletes should be aware of the potential risks of taking this drug.
The most common side effects of Exemestane include the following:
Less common side effects include:
Exemestane is usually taken in doses of 25-50mg per day. It can be taken alone or in combination with other drugs such as anabolic steroids, non-aromatizing steroids, growth hormones, insulin, and weight loss drugs.
It can be combined with other drugs for mass-building and cutting. For mass-building, it can be combined with anabolic steroids such as testosterone and trenbolone, as well as other drugs such as growth hormone and insulin. For cutting, it can be combined with non-aromatizing steroids such as stanozolol and oxandrolone and other drugs such as clenbuterol and albuterol.
Exemestane should be used cautiously in patients with hepatic or renal impairment. Tell your doctor and pharmacist your medical history and other medications that are previously taken so they can guide you or prevent you from allergic reactions to the said drug. Always disclose other prescription and non-prescription drugs you have, whether vitamins, supplements, or other herbal supplements that may have contraindications. Run some blood tests to monitor if said drug will suit your need.
It is always advisable to consult your physician first before going through the treatment using Exemestane. Results and reactions may always vary among patients.
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