Active substance: Sildenafil Citrate
Names: Viagra, Agra, Sildenafil.
Vigrande made by Zentiva is used to treat erectile dysfunction/impotence in men by relaxing the muscles of the blood vessels and increases blood flow to particular areas of the body.
Sildenafil Citrate (Chemical Formula is C₂₈H₃₈N₆O₁₁S) is famously known as a medication to treat erectile dysfunction in men and pulmonary arterial hypertension. In 1989, the pharmaceutical company Pfizer originally discovered this drug while looking for a heart-related chest pain treatment. It was only then in 1998 that it was approved for medical use in the United States and Europe. It has been ranked as the 217th most commonly prescribed medication in the United States garnering almost two million prescriptions issued in 2017.
The term Sildenafil Citrate is used to refer to the citrate salt form of Sildenafil. It is categorized as a pyrazolopyrimidinone derivative having vasodilating properties with prospective anti-inflammatory characteristics. Sildenafil prevents cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) which results in cGMP availability decreasing its degradation. With this having said, it promotes prolonged penile erection because it provides muscle relaxation in the corpus cavernosum of the penis due to vasodilation and blood engorgement. Additionally, because this drug smooth and relaxes the muscle of the pulmonary vascular bed, the pulmonary hypertension is lessened resulting in relief in the blood flow of the lungs. Sildenafil enables the reduction of inflamed airway and mucus production.
Apparently, there is not much difference between the two aside from the fact that Taladafil lasts longer than Sildenafil. 36 hours longer for Taladafil while Sildenafil lasts for only 4-5 hours.
In case of the side effects that are written below, STOP immediately the sildenafil and get emergency medical help:
Precautions Before Taking Sildenafil Citrate
Always take necessary precautions when taking medications to treat sexual dysfunctions since the effects may vary in different situations and conditions of patients.
Tell your doctor and pharmacist about your medical history if you have conditions such as priapism (erection that won’t go away), dehydration, or a smoker. Other medications previously taken should also be disclosed so they can guide you or prevent you from having an allergic reaction to the said drug. Always disclose other prescription and non-prescription drugs you have whether it is vitamins, supplements, or other herbal supplements that may have a contraindication.
Vigrande is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Vigrande more than once per day.
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