Active substance: Clomiphene Citrate
Names: Clomed, Clomid, Serophene.
Clomiphene Citrate (Chemical Formula is C₂₆H₂₈ClNO) is a drug used to treat infertility in women who are not able to ovulate, this is including but is not limited to those who suffer from polycystic ovary syndrome. In 1956, a team led by Dr. Palopoli at William S. Merrell Chemical Company created Clomiphene Citrate after it was recorded that biological activity has been monitored and showed promising effects on a confirmed patient in November 1959. This drug was described to initially treat advanced breast cancer cases during the years 1964 to 1974.
Clomiphene Citrate is the citrate salt form of clomiphene wherein the triphenylethylene non-steroidal agent can inhibit the synthesis of cancer cells. This substance has both estrogenic and anti-estrogenic activities that contest with estrogen for binding at estrogen receptor sites in target tissues. This occurrence causes the release of the pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) that helps ovulation easier. Additionally, it is a long-acting estrogen receptor binding, with nuclear retention of 48 hours or greater. Even if Clomiphene Citrate has some estrogen effect, its anti-estrogenic property has been found out to be one of the main sources for the stimulation of the ovaries.
Clomiphene Citrate is presented as a form of estrogen, having a structure similar to that of tamoxifen. Being given to men Clomiphene Citrate acts as an anti-estrogen in case they are given steroids that bringing flavored light effects. Clomiphene Citrate is thinner than Provimed and Tamoxifen. Because it leads to stimulation of gonadotropins, it makes increases endogenous testosterone levels. This is exactly welcome at the end of a course of steroids when testosterone levels are low. Clomiphene Citrate combines well with Tamoxifen.
During the cycle, as an anti-estrogen, it is good to combat gynecomastia. But it is recommended to use Anastrozole or other AI products on the cycle in exchange for Clomiphene Citrate. When anabolic steroids are used, the natural testosterone lever is suppressed drastically, and here comes Clomiphene Citrate to help, as, without it, you will need more time and effort to recover the natural testosterone production.
Clomiphene Citrate is administered in doses of 250-300 mg the first day, after that 100-200 mg per day the next 10 days, and 50-100 mg per day the last 10 days. The dose is taken within 7-21 days after completion of the cycle to normalize the own production of testosterone. Can be combined with other post-cycle therapy drugs.
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Tell your doctor and pharmacist your medical history and other medications are previously taken so they can guide you or prevent you from having an allergic reaction to the said drug. Always disclose other prescription and non-prescription drugs you have whether it is vitamins, supplements, or other herbal supplements that may have a contraindication.
It is always advisable to consult your physician first on which pharmaceutical drug is best for your need—whether you have a worst-case or otherwise because dosages and indications may vary to different patients.
If used in large doses visual disturbances may occur or stains. They disappear after few days. If these symptoms persist longer stop taking it.
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