Active substance: Clomiphene Citrate
Names: Clomed, Clomid, Serophene.
Clomiphene Citrate (Chemical Formula is C₂₆H₂₈ClNO) is a drug used to treat infertility in women unable to ovulate. This includes but is not limited to those who suffer from polycystic ovary syndrome. In 1956, a team led by Dr. Palopoli at William S. Merrell Chemical Company created Clomiphene Citrate after it was recorded that biological activity had been monitored and showed promising effects on a confirmed patient in November 1959. This drug was described to treat advanced breast cancer cases from 1964 to 1974 initially.
Clomiphene Citrate is the citrate salt form of clomiphene wherein the triphenylethylene non-steroidal agent can inhibit the synthesis of cancer cells. This substance has both estrogenic and anti-estrogenic activities that contest with estrogen for binding at estrogen receptor sites in target tissues. This occurrence causes the release of pituitary gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH), which helps ovulation easier. Additionally, it is a long-acting estrogen receptor binding, with nuclear retention of 48 hours or more significant. Even if Clomiphene Citrate has some estrogen effect, its anti-estrogenic property is one of the primary sources for stimulating the ovaries.
Clomiphene Citrate is presented as a form of estrogen, having a structure similar to that of tamoxifen. Being given to men, Clomiphene Citrate acts as an anti-estrogen in case they are given steroids that bring flavored light effects. Clomiphene Citrate is thinner than Provimed and Tamoxifen. Because it leads to the stimulation of gonadotropins, it makes increases endogenous testosterone levels. This is welcome at the end of a course of steroids when testosterone levels are low. Clomiphene Citrate combines well with Tamoxifen.
During the cycle, as an anti-estrogen, it is good to combat gynecomastia. But using Anastrozole or other AI products on the cycle is recommended in exchange for Clomiphene Citrate. When anabolic steroids are used, the natural testosterone level is suppressed drastically, and here comes Clomiphene Citrate to help, as, without it, you will need more time and effort to recover the natural testosterone production.
Clomiphene Citrate is administered in doses of 250-300 mg the first day, after that 100-200 mg per day the next ten days, and 50-100 mg per day the last ten days. The dose is taken within 7-21 days after the cycle's completion to normalize the production of testosterone. It can be combined with other post-cycle therapy drugs.
Tell your doctor and pharmacist about your medical history whether you are:
Tell your doctor and pharmacist your medical history and other medications that are previously taken so they can guide you or prevent you from having an allergic reaction to the said drug. Always disclose other prescription and non-prescription medicines, such as vitamins, supplements, or other herbal supplements that may have a contraindication.
It is always advisable to consult your physician on which pharmaceutical drug is best for your need—whether you have a worst-case or otherwise because dosages and indications may vary for different patients.
If used in large doses, visual disturbances or stains may occur. They disappear after a few days. If these symptoms persist longer, stop taking them.
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