Name
Danabol
INN of the active substance
Methandienonum
Composition of the preparation
1 tablet contains:
active substance: metandienonă 10 mg;
Additional ingredients: magnesium stearate, ludipress (lactose, povidone, crospovidone).
Pharmaceutical Form
Tablets.
Pharmacotherapeutic group and ATC code
Аnabolizant. A14A A03
Pharmacological properties
Pharmacodynamic properties.
Methandienone is an anabolic steroid. By entering the nucleus of the cell, stimulating the genetic apparatus of the cell, leading to increase synthesis of DNA, RNA and structural proteins, activate the respiratory chain enzymes tissue and enhancing tissue respiration, the oxidative phosphorylation, ATP synthesis and assembly of intracellular macroregion. Stimulates anabolic processes and inhibit them in the catabolic caused by glucocorticoids. Leads to increased muscle mass, reduce fat deposits, improves trophic tissues, promotes calcium deposits in the bones, retain nitrogen, phosphorus, sulfur, potassium, sodium and water in the body. Hematopoietic growth is determined by the action of erythropoietin synthesis. Androgenic action (moderate) may contribute to the development of masculine secondary sexual characteristics.
Pharmacokinetic properties.
It is rapidly and completely absorbed in TGI, low bioavailability is determined by the presence of transition effect by first pass metabolism. The set of carriers according to the specific globulin 90%. It is subject to final biotransformation in the liver to form inactive metabolites. Renally excreted.
Duration - up to 14 hours.
Indications
Protein synthesis disorders, cachexia diverse genesis; trauma, burns, pre-and postoperative periods after infectious diseases and radiation; renal and adrenal, toxic goiter, muscular dystrophy, osteoporosis, negative nitrogen balance corticosteroid therapy, and aplastic anemia hypo. Adjunct in the treatment of tuberculosis, osteomyelitis, asthma, hepatitis.
Dosage and method of administration:
Adults - initial dose 10-20 mg / day. The maintenance dose is 5-10 mg / day. The maximum dose - 50 mg / 24 hours.
Children: up to 2 years - 0.04 mg / kg; 2-6 years - 0.5 mg / kg; 6-14 - 1 mg / kg in 1-2 doses. The cure - up to 4 weeks. Clean repeated - over 6-8 weeks.
Side effects:
Women - virilization symptoms, inhibition of ovarian function, menstrual disorders, hypercalcemia.
Men: in prepubertal - virilization symptoms, skin hyperpigmentation idiopathic withholding or stopping the growth (calcification of epiphyseal growth zones tubular bones); during postpubertal - bladder irritation, gynecomastia, priapism; in the elderly - hypertrophy and / or prostatic carcinoma.
Men and women - the progression of atherosclerosis, peripheral edema, impaired liver function with jaundice, changes in blood count, bone pain sockets, hypo coagulation prone to bleeding.
Contraindications:
Hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, CPI, severe atherosclerosis, hepatic and renal function, acute and chronic prostatitis, pregnancy and lactation.
Overdose
Cases of overdose have not been reported.
Warnings and special precautions for use:
Children are recommended after one month of treatment, rest for 1-2 months.
The first signs of virilization of patients (deepening of the voice, hirsutism, acne, clitoromegaly) administration must be stopped to avoid irreversible changes. A systematic control the lipidemic and cholesterol.
Interactions with other drugs
Increases the action of anticoagulants, antiplatelet, remedies hypoglycemic, just enhances the hepatotoxic side effects of remedies.
Storage:
Store in a dry place protected from light, at a temperature of 15-25 ° C.
Keep out of reach of children.
Shelf life:
Three years. Do not use after the expiration date indicated on the packaging.
