Active substance: Anastrozole
Names: Arimidex, Anastrozol.
Anastrozole (Chemical Formulation is C₁₇H₁₉N₅) is a non-steroidal benzyl triazole drug medication used to treat breast cancer, specifically hormone receptor-positive and high-risk breast cancer. It was patented in 1987 by Imperial Chemical Industries and consequently approved for medical use only in 1995. The World Health Organization has included this drug in the List of Essential Medicines, which is available as a generic medication. It was ranked 258th most commonly prescribed drug medication in the United States in 2017, garnering more than a million prescriptions.
It is considered a non-steroidal inhibitor of estrogen synthesis. It is a third-generation aromatase inhibitor that selectively binds and reverses the inhibition of aromatase. This cytochrome P-450 enzyme complex can be found in tissues in the premenopausal ovary, liver, and breast. For most estrogen-dependent breast cancers, Anastrozole may aid in preventing the development of tumors and advanced cancers because it reversibly binds aromatase enzymes and prevents the transformation of androgens to estrogens in tissues causing cancer. The decrease in the aromatase action results in a decrease in estradiol levels in at least 85% of post-menopausal women, making it an efficient prescribed treatment.
Anastrozole, made by Zerox Pharmaceuticals, is a potent anti-estrogen drug. The active substance is used for fighting breast cancer. It is an inhibitor of flavoring. A practical laboratory demonstrated that a daily pill is enough for good effects. In steroid cycles, this substance is used from 0.25mg up to 1mg. Anastrozole inhibits the enzyme action that causes testosterone aromatization. When it says that testosterone turns into estrogen, then testosterone is altered by this enzyme, leading to the production of estrogen in the body with harmful effects such as gynecomastia, weight gain, water retention, and oily skin. Many people do not want low estrogen levels because it helps build muscle mass, so they use drugs to limit these effects, such as Tamoxifen or Clomirox. Anastrozole is used by those who want the complete elimination of estrogen during a steroid cycle. Anastrozole is a perfect option for those who opt for more defined muscles and those who are sensitive to estrogen. The optimal dose is 0.5-1 mg anastrozole 1 mg is the maximum that can be given.
Those who follow the Testosterone based steroid cycle with a dose of 500 mg per week will receive anastrozole of 0.5 mg every two days.
Anastrozol can be used to treat the following:
As for anabolic steroid users, the Anastrozol effects are welcome since they can protect against estrogen-related side effects. Due to testosterone hormones that interact with the aromatase enzyme, in many cases, it promotes estrogenic side effects that can lead to gynecomastia and excess water retention. At the same time, if the water retention excesses, it can lead to high blood pressure. Some steroids don't aromatize and, at the same time, don't lead to estrogenic-related effects. Still, Dianabol, Nandrolone, Boldenone esters, and especially all testosterone esters, can promote estrogenic side effects.
That is why it is essential to add Anastrozole in steroid cycles that contain aromatizing steroids, which can protect against gyno and water retention. At the same time, it protects against high blood pressure. Yes, some steroids can cause high blood pressure even without water retention. Still, in the case of very high excess water retention, it could increase drastically the high blood pressure, which can lead to significant issues. Anastrozole doesn't protect at 100% from the gynecomastia side effects, but it is one of the most used and effective AI products for combating estrogenic-related side effects. SERMs like Tamox can be used during the cycle as AI products but are mainly used during the PCT program.
Anastrozole is not the best option to be used during the PCT program because of the effect of lowering estrogen, which is why it is not recommended when you have a low testosterone level. The main object of a PCT program is to stimulate natural testosterone production to protect the lean muscle tissues received after the steroid cycle, recover the testicles, keep the body fat under control, and recover your body health faster from high dosages of testosterone.
For medical use to treat breast cancer, use 1mg per day of Anastrozole until cancer subsides. After that, Tamox should be taken for a period to prevent cancer remission.
For anabolic steroid users, the most common are the dosage from 0.5 up to 1mg every other day (EOD), depending on the steroid dosages used during the cycle.
When Anastrozole is taking not during a steroid cycle, it can lead to some side effects such as weakness and fatigue. These side effects rarely occur when it is used during the steroid cycle.
Another possible side effect:
Anastrozole can negatively affect cholesterol levels primarily when it is used during a testosterone cycle. That is why a good diet with low and minimal saturated fats and simple sugars is welcomed during the cycle. Don't forget the Omega fatty acids, vitamins, and antioxidant cholesterol supplement.
Precautions Before Taking Anastrozole
Tell your doctor and pharmacist your medical history and other medications that are previously taken so they can guide you or prevent you from having an allergic reaction to the said drug. Always disclose other prescription and non-prescription drugs, such as vitamins, supplements, or other herbal supplements that may be contraindicated.
It is always advisable to consult your physician on which pharmaceutical drug is best for your need—whether you have a worst-case or otherwise because dosages and indications may vary for different patients.
Always remember that Anastrozole cannot be taken by women who are not diagnosed to be in a menopausal stage. While pregnant should be checked and approved by a doctor.
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